Everything about ceesdekker
Everything about ceesdekker
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Rotary movement of DNA rotors on nanopores. Leading row: Uncooked video clip of the Cy5 channel of each and every rotor. Middle row: corresponding one-particle localization outcomes of the two ends with the DNA rotors. The place of the present frame is marked as orange and blue dots, as well as trajectory of The ten frames ahead of the current frame is proven as good traces.
1996, 1st mesoscopic demand density waves gadgets; and 1st electrical measurements on only one metal nanocluster amongst nanoelectrodes
[Laughs] ‘It absolutely was surely an incredible possibility! At the time, I had been perfectly knowledgeable that it could go Erroneous and that I could grow to be much less successful, but I just dismissed that. Curiosity has usually been my strongest driving force. And fortunately everything worked out.’
Our perform was speedily followed up by Other folks, most notably by Phaedon Avouris and colleagues at IBM, who in October 1998 published their findings on transistors produced from single- and multi-walled carbon nanotubes in Applied Physics Letters.
2015, discovery that condensin can be a extremely adaptable protein framework; and initial detection of DNA knots using nanopores
Cornelis (Cees) Dekker (Haren, seven april 1959) is een Nederlandse natuurkundige en universiteitshoogleraar verbonden aan de Technische Universiteit Delft. Van 2010 tot en achieved 2018 was hij tevens directeur van het Kavli Institute of Nanoscience in Delft. Zijn vakgebied is de moleculaire biofysica; hierbij beweegt hij zich op het grensvlak van de natuurkunde en de biologie waarbij hij gebruikmaakt van de zogeheten nanotechnologie, de technieken om aan enkele atomen en moleculen te kunnen meten.
We use nanofabricated microfluidic structures to pattern spatial boundaries for bacteria and biomimetic vesicles with reconstituted protein networks and this assess the elemental job of spatial confinement at the molecular and mobile amount. Our initiatives include things like the subsequent:
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The rotors harness Vitality from a nanoscale h2o and ion circulation which is generated by a static chemical or electrochemical opportunity gradient from the nanopore, that happen to be set up via a salt gradient or utilized voltage, respectively. These artificial nanoengines self-Arrange and function autonomously in physiological conditions, suggesting solutions to constructing Electricity-transducing motors at nanoscale interfaces.
There was a single dilemma while — we did not observe any measurable electrical conduction from the single polymer molecules. We concluded that at The only-molecule level, conducting polymers had been truly not these types of wonderful conductors, which was relatively disappointing. We Consequently broadened our perspective to try to search out additional promising molecules.
Testing pseudotopological and nontopological types for SMC-pushed DNA loop extrusion towards roadblock-traversal experiments
Nanoscientist Cees Dekker is really an amiable and flamboyant male who appears A lot younger compared to the sixty two yrs he in fact is – trendy glasses, psychedelic shirt, partaking smile – although not a single to waste time. He usually takes his time, but not more than vital.
2008, 1st observation of protein-coated DNA translocation by way of nanopores; solved the origin on the electrophoretic pressure on DNA in nanopores; uncovered a major velocity enhance of microtubules in electrical fields; identified an anomalous electro-hydrodynamic orientation of microtubules; and settled the origin of sound in carbon nanotubes in liquid
2004, discovery of latest physics in translocation of DNA by way of nanopores; very first experimental study of ions conduction in nanofluidic channels; initially cees dekker electrochemistry with particular person solitary-wall carbon nanotubes; STM detection and Charge of phonons in carbon nanotubes; 1st electrical docking of microtubules on kinesin-coated nanostructures; initially biophysics characterization in the mechanical properties of double-stranded RNA; and very first one-molecule examine of DNA translocation by a restriction-modification enzyme.